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Posted On Jun 23, 2025

Updated On Jul 01, 2025

IV Fluid Selection In Addison's Disease - Concern About Sodium?

Emergency & Critical Care

This question was submitted in relation to a past webinar titled Canine Addison's Disease ...

Question:
I was recently told by a specialist not to give NaCl as an IV fluid for an Addison's case, because it would increase the sodium levels too quickly. They recommended I use Hartmanns instead. Your thoughts on this, please.

Answer by Elisa Mazzaferro, MS, DVM, PhD, DACVECC:
In animals that have severe hyponatremia (Na+ < 130 meq/L) yes, I would  be concerned about raising the sodium too quickly as 0.9% NaCl has 154 mEq/L of sodium and could potentially lead to central pontine myelinolysis if the sodium raises by more than 15 mEq/L in a 24 hour period.

Hartmanns / Lactated Ringers solution has ~ 130 mEq/L of sodium, so is a good fluid for intravascular volume expansion and interstitial dehydration that won't raise the sodium too quickly.