Corresponding author, Katie Tolbert, DVM, PhD, DACVIM has indicated the following comments regarding this EBU:
"We actually placed the pH capsules on day 4 not day 1 as indicated in the EBU. We were interested in comparing the effect of acid suppressants when dosed chronically which is the reason for waiting until all drugs were at steady state. Also, she may be interested to read Dr. Quimby's paper on gastrin and CKD in cats (J Vet Intern Med. 2014 May-Jun;28(3):827-37). Interestingly, they found no evidence for erosive or ulcerative gastritis in cats with CKD (despite high serum gastrin). In fact, the cats had evidence of gastric gland atrophy so the use of acid suppressants in cats with CKD has become somewhat muddy!"
Corresponding author, Katie Tolbert, DVM, PhD, DACVIM has indicated the following comments regarding this EBU:
"We actually placed the pH capsules on day 4 not day 1 as indicated in the EBU. We were interested in comparing the effect of acid suppressants when dosed chronically which is the reason for waiting until all drugs were at steady state. Also, she may be interested to read Dr. Quimby's paper on gastrin and CKD in cats (J Vet Intern Med. 2014 May-Jun;28(3):827-37). Interestingly, they found no evidence for erosive or ulcerative gastritis in cats with CKD (despite high serum gastrin). In fact, the cats had evidence of gastric gland atrophy so the use of acid suppressants in cats with CKD has become somewhat muddy!"
