Systemic feline diseases (parasitic, bacterial, fungal, viral, neoplastic, metabolic, vascular, and immune-mediated) are often associated with ocular symptoms.  An ocular examination is an important diagnostic tool and should be part of any physical examination.  Conversely, cats afflicted with systemic disease require periodic ocular examinations for prognostic information and to prevent vision threatening complications.  Typical feline systemic diseases encountered by the practicing clinician are presented with their commonly associated ocular signs.