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• Osteosarcoma in Dogs
• Incidence and Risk Factors
• Etiology
• Physical Factors
• Genetic Factors
• Molecular Factors
• Pathology and Natural Behavior
• History and Clinical Signs
• Systemic Alterations
• Diagnostic Techniques and Work-Up
• Radiology
• Tissue Biopsy
• Staging and Patient Assessment
• Known or Suggested Prognostic Factors
• Anatomic Location and Signalment
• Therapy Directed at the Primary Tumor
• Surgery
• Nonsurgical Alternative Methods of Limb Salvage
• Intraoperative Radiation Therapy and Extracorporeal Intraoperative Radiation Therapy
• Stereotactic Radiosurgery
• • Isolation of Limb Circulation and Perfusion
  • Summary of Outcome Following Limb Salvage for Dogs with Osteosarcoma
  • Surgery for Nonappendicular and Less Common Appendicular Sites of OS
  • Radiation
  • Radioisotopes
  • Systemic Adjuvant Therapy for Dogs with Osteosarcoma
  • Chemotherapy
  • Cisplatin: Single Agent
  • Carboplatin: Single Agent
  • Lobaplatin: Single Agent
  • Doxorubicin: Single Agent
  • Doxorubicin/Cisplatin: Concurrent Combination
  • Doxorubicin/Carboplatin: Concurrent Combination
  • Doxorubicin/Cisplatin: Alternating Combination
  • Doxorubicin/Carboplatin: Alternating Combination
  • Carboplatin/Gemcitabine: Concurrent Combination
  • Preliminary Agents
    • Immunotherapy
    • Molecular-Targeted Therapies for Dogs with Osteosarcoma
    • Micrometastatic Adjuvant Setting
    • Treating Gross Metastatic Disease
    • Surgery
    • Chemotherapy and Receptor Tyrosine Kinase Inhibitors for Gross (Macroscopic) Osteosarcoma
    • Investigational Therapies for Gross Metastatic Disease
    • Aerosol Drug Delivery
    • Augmentation of Antitumor Immunity
    • Palliative Treatment: Primary and Metastatic Bone Cancer Pain
    • Bone Cancer Pain Physiology
    • Palliative Radiation Therapy
    • Radiopharmaceuticals
    • Aminobisphosphonates
    • Comparative Aspects
    • Bone Surface Osteosarcoma
    • Other Primary Bone Tumors of Dogs
    • Chondrosarcoma
    • Hemangiosarcoma
    • Fibrosarcoma
      • Multilobular Osteochondrosarcoma
      • Metastatic Tumors of Bone
      • Benign Tumors of Bone
      • Osteomas
      • Multiple Cartilaginous Exostosis
      • Bone Cysts
      • Primary Bone Tumors of Cats
      • Incidence and Risk Factors
      • Pathology and Natural Behavior
      • History and Clinical Signs
      • Diagnostic Work-Up
      • Therapy and Prognosis
      • Fibrosarcoma, Chondrosarcoma, and Hemangiosarcoma
      • References