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General Principles of Cancer Chemotherapy
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Mechanism of Cancer Therapy
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Terminology and Concepts
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Indications and Goals of Therapy
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Tumor Susceptibility and Resistance
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Tumor Cell Sensitivity
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Tumor Cell Resistance
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Combination Therapies
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Toxicities Associated with Drug Therapy of Cancer
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Safety Concerns of Cancer Drug Therapy
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Pharmacologic Principles in Cancer Therapy
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Pharmacokinetics
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Pharmacodynamics
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Pharmaceutics
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Specific Chemotherapeutic Agents
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Alkylating Agents
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Nitrogen Mustards
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Nitrosoureas
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Other Alkylating Agents
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Antitumor Antibiotics
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Doxorubicin
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Mitoxantrone
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Actinomycin D (Dactinomycin)
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Antimetabolites
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Cytosine Arabinoside (Cytarabine)
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Methotrexate
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Gemcitabine
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5-Fluorouracil
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Antimicrotubule Agents
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Taxanes (Paclitaxel and Docetaxel)
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Vinca Alkaloids (Vinblastine and Vincristine)
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Topoisomerase Inhibitors
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Epipodophyllotoxins (Etoposide and Teniposide)
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Steroids
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Prednisone
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Others
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Platinum (Carboplatin and Cisplatin)
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Hydroxyurea
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L-Asparaginase
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Future Directions in Drug Therapies for Cancer
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Individualized Dosing
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Population Pharmacokinetics
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Molecular Profiling
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Tumor Sensitivity
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Prognostic Evaluation
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Novel Combinations
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References
