Gastrointestinal upset is one of the more common adverse effects associated with oral antibiotic administration. This is often referred to as antibiotic-associated gastrointestinal signs (AAGS), and it can occur in both humans and animals. These signs include diarrhea, vomiting, and loss of appetite.
Adverse drug effects of any type are a common cause of noncompliance or prematurely discontinuing a prescribed course of antibiotic therapy. Failure to complete a full course of antibiotics may result in a prolonged illness or complications due to an unresolved infection, as well as lead to the development of antibiotic resistance.
In humans the administration of probiotics in conjunction with antibiotics has been shown to significantly decrease AAGS, however studies have been lacking to support this practice in veterinary patients. In this week's Specialty Update, Dr. Elisabeth Zenger summarizes the findings of a recently published study that examined the effects of a synbiotic (pre- and probiotic supplement) on animals administered Clindamycin - an antibiotic known to cause AAGS. Discussion also includes the "Specialist's Spin" and considerations regarding antibiotic administration, AAGS, and use of probiotics. Here's a preview:
View this in its entirety (running time: 11 mins)
